Frontiers

Sex-divergent intrinsic brain function in Parkinson’s disease: elevated nigral fluctuations and premotor-visuospatial coupling in female patients

Cortical and subcortical alterations in brain intrinsic function have been widely reported in Parkinson’s disease (PD). However, sex differences in brain intrinsic function in PD are poorly understood ...
Frontiers

HCN4 gain-of-function mutation increases intrinsic heart rate and limits maladaptive remodeling under pressure overload

Gain-of-function (GOF) mutations in the cardiac pacemaker channel HCN4 have been associated with inappropriate sinus tachycardia in human patients. Chronic tachycardia is generally associated with ...
Nature

PLD1 and PLD2 promote an immunosuppressive tumor microenvironment via CCL19-dependent macrophage polarization and PD-L1 induction

Tumor cells shape the immunosuppressive tumor microenvironment (TME) through coordinated interactions with tumor-associated macrophages (TAMs), regulatory T cells (T regs), immune checkpoint pathways ...
IEEE

Service Function Chain Deployment With Intrinsic Dynamic Defense Capability

Abstract: The Service Function Chain (SFC) leverages Network Function Virtualization (NFV) and Software-Defined Networking (SDN) for flexible deployment, creating customized service chains tailored to ...
IEEE

Differentiation of Benign and Malignant Masses in Mammogram Using 2D-Fourier–Bessel Intrinsic Band Functions and Improved Feature Space

Abstract: This article proposes a framework based on the 2D-Fourier–Bessel decomposition method (2D-FBDM) and improved feature space for the automatic diagnosis of benign and malignant masses in ...